A philanthropist who will remain anonymous recently asked Nick Beckstead, a trustee of 80,000 Hours, what he would do with a very large amount of money.
Nick, with support from Carl Shulman (a research advisor to 80,000 Hours), wrote a detailed answer: A long-run perspective on strategic cause selection and philanthropy.
If you’re looking to spend or influence large budgets with the aim of improving the world (or happen to be extremely wealthy!) we recommend taking a look. It also contains brief arguments in favor of five causes.